|
KMID : 0525720090140030149
|
|
Journal of Chitin and Chitosan
2009 Volume.14 No. 3 p.149 ~ p.154
|
|
|
Chitosan Oligosaccharides Prevent CCl4-induced Nephrotoxicity in the Rat Kidney
|
|
Kang Ki-Young
Kim Jung-Woo
|
|
|
Abstract
|
|
|
|
Carbon tetrachloride (CCl4) is a potent hepatotoxic and nephrotoxic material. CCl4-induced organotoxicity is resulted from the reactive radicals produced by biochemical processes. Recently, it is known that chitosan oligosaccharides (COS) have antioxidative properties. Therefore, we intended to investigate the protective effects of COS against the CCl4-induced nephrotoxicity model. CCl4 (1 ml/kg) was administrated to Sprague-Dawley rats once a week for 4 weeks and COS (100 mg/kg) was given daily for 4 weeks. Animals were sacrificed under ether anesthesia, and then whole blood and kidneys were obtained. COS treatment decreases blood urea nitrogen and serum creatinine levels of the CCl4 administered rats in serological analysis. It also prevents histopathological alterations of the CCl4 intoxicated kidney including glomerular congestion, glomerular atrophy and deterioration of renal tubular epithelium. By the immunohistochemistry, COS treatment reduces expressions of the transforming growth factor beta-1 (TGF-β1) and its receptors in the CCl4 intoxicated rat kidney. According to these data, COS is effective renoprotecitve material against the progression of CCl4-induced renal injury.
|
|
|
KEYWORD
|
|
|
CCl4, kidney, chitosan oligosaccharides, TGF-β1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|